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doi: 10.3389/fimmu.2025.1558414 Received 13 January 2025 Accepted 04 February 2025 Published 21 February 2025 Volume 16 - 2025 Edited by Jin-Yi Wan, Beijing University of Chinese Medicine, China Reviewed by Hui Ye, Peking University, China Ke Xiao, Shandong University, China Weihan Zhao, Shaanxi University of Chinese Medicine, China Updates Copyright 2025 Guan, Cheng, Zhang, Cai, Zhang, Jiang, Wang, Zeng and Jia

Powerful glycemic control with compelling weight loss with Ozempic (semaglutide) injection 1 (semaglutide) injection 1 Ozempic is not indicated for weight loss Ozempic vs Lantus and Ozempic 1 mg vs 2 mg 1 Primary endpoint: change in A1C from baseline SUSTAIN 4: vs study-titrated Lantus 1,5 In insulin-nave adult patients with type 2 diabetes on metformin sulfonylurea Mean change in A1C from baseline at Week 30 Mean baseline A1C: 26% of insulin patients titrated to goal by Week 30

FIGURE 7 In summary, PCs participate in T2DM pathophysiology via multiple mechanisms, such as enhancing insulin secretion, safeguarding pancreatic -cells, optimizing mitochondrial function and insulin resistance, and regulating hepatic lipid metabolism

Therefore, its stimulation of the NO-system is not simple, uncontrolled activation but rather a highly controlled and regulated effect

In effect, arsenate uncouples the GAPDH and PGK reactions